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Article

A common region of homozygous deletion in malignant human gliomas lies between the IFN alpha/omega gene cluster and the D9S171 locus.

Cancer research - 15 Jun 1994

Ichimura K, Schmidt E E, Yamaguchi N, James C D, Collins V P

Abstract excerpt

Deletions of the 9p-localized type-I interferon (IFN) genes and adjacent loci often occur during the development of malignant glioma. We have applied restriction fragment length polymorphism and microsatellite analysis to 12 loci covering this region of 9p and 3 loci on 9q in 74 human glial tumor tissues to define and further localize the smallest region of hemizygous or homozygous deletion common to the tumors....

Topics

Alleles
Astrocytoma
Brain Neoplasms
Chromosomes, Human, Pair 9
Gene Deletion
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Genetic Variation
Glioblastoma
Glioma
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon Type I

Multigene Family

Source

Identifiers

PMID: 8205529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8205529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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