Article
Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers.
Journal of the National Cancer Institute - 16 Aug 1995
Kishimoto Y, Sugio K, Hung J Y, Virmani A K, McIntire D D, Minna J D, Gazdar A F
Abstract excerpt
BACKGROUND: Carcinogenesis is a multistep process, which may begin as a consequence of chromosomal changes. Deletions in the short arm of chromosome 9 (9p) have been observed in lung carcinomas. In addition, morphologically recognizable preneoplastic lesions, frequently multiple in number, precede onset of invasive carcinomas. PURPOSE: We tested for deletions and loss of heterozygosity (LOH) at 9p loci in...
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