Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers.

doi:10.1093/jnci/87.16.1224

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Article

Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers.

Journal of the National Cancer Institute - 16 Aug 1995

Kishimoto Y, Sugio K, Hung J Y, Virmani A K, McIntire D D, Minna J D, Gazdar A F

Abstract excerpt

BACKGROUND: Carcinogenesis is a multistep process, which may begin as a consequence of chromosomal changes. Deletions in the short arm of chromosome 9 (9p) have been observed in lung carcinomas. In addition, morphologically recognizable preneoplastic lesions, frequently multiple in number, precede onset of invasive carcinomas. PURPOSE: We tested for deletions and loss of heterozygosity (LOH) at 9p loci in...

Topics

Adenocarcinoma
Aged
Aged, 80 and over
Alleles
Base Sequence
Carcinoma, Non-Small-Cell Lung
Chromosome Deletion
Chromosomes, Human, Pair 8
Female
Genes, ras
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lung Neoplasms

Male

Middle Aged

Molecular Sequence Data

Mutation

Paraneoplastic Syndromes

Source

Open in PubMed

Identifiers

PMID: 7563168
DOI: 10.1093/jnci/87.16.1224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7563168-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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