Loss of 9p leads to p16<sup>INK4A</sup> down‐regulation and enables RB/E2F1‐dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs)

doi:10.1002/path.2352

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Article

Loss of 9p leads to p16<sup>INK4A</sup> down‐regulation and enables RB/E2F1‐dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs)

18 Mar 2008

Abstract excerpt

Loss of chromosome 9p is a reliable predictor of malignant behaviour in gastrointestinal stromal tumours (GISTs). p16INK4A located at 9p21 inhibits the CDK4/6/cyclin D complex from phosphorylating RB. Phosphorylation of RB through CDK4/6/cyclin D in early G(1) phase frees the transcription factor E2F1 from RB and enables mRNA transcription of genes essential for G(1)/S phase transition. This study aims to...

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PMID: 18438954
DOI: 10.1002/path.2352

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