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Article

9p21 deletion correlates with recurrence in head and neck cancer

1 Mar 1998

Abstract excerpt

BACKGROUND: Deletion of 9p21 is a common event in many human tumors, including head and neck squamous cell carcinoma (HNSCC). The gene CDKN2, which encodes the protein p16, a cyclin-dependent kinase-4 inhibitor, maps to 9p21. The role of CDKN2 as the tumor suppressor gene in these neoplasms is unclear. The role of loss of heterozygosity (LOH) as a prognostic tool has not been described in HNSCC. METHODS: We...

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PMID: 9484941
DOI: 10.1002/(sici)1097-0347(199803)20:2<113::aid-hed3>3.0.co;2-5

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