Article
Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion.
International immunology - 1 May 1998
Senoo M, Shinkai Y
Abstract excerpt
During the thymic development of alphabeta lineage T cells, maturation of the CD4- CD8- double-negative (DN) cells into the CD4+ CD8+ double-positive cells is accompanied by the induction of TCR beta allelic exclusion. Recent studies have shown that these events are regulated by the signals throu...
Topics
- Alleles
- Animals
- Base Sequence
- CD3 Complex
- DNA Methylation
- DNA Nucleotidyltransferases
- DNA Primers
- DNA-Binding Proteins
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell, alpha-beta
- Signal Transduction
- T-Lymphocyte Subsets
- Transcription, Genetic
- VDJ Recombinases