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Article

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.

Nature - 19 Nov 1992

Mombaerts P, Clarke A R, Rudnicki M A, Iacomini J, Itohara S, Lafaille J J, Wang L, Ichikawa Y, Jaenisch R, Hooper M L

Abstract excerpt

Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.

Topics

Animals
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes
CD8 Antigens
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genes, RAG-1
Leukocyte Count
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mice, Transgenic

Mutation

Thymus Gland

Source

Identifiers

PMID: 1359428
DOI: 10.1038/360225a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1359428-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.PMID 1359428Read ↗

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