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Article

RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells.

Immunity - 1 Nov 1998

McMahan C J, Fink P J

Abstract excerpt

Under most circumstances, allelic exclusion at the T cell receptor (TCR)beta locus is tightly regulated. Here, we describe a system in which TCRbeta allelic exclusion is overcome as a result of V(D)J recombination in peripheral CD4+ T cells. In TCRbeta chain transgenic mice, tolerogen-mediated chronic peripheral selection against cells expressing the transgene leads to surface expression of endogenous TCRbeta...

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Source

Identifiers

PMID: 9846485
DOI: 10.1016/s1074-7613(00)80661-5

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells.PMID 9846485Read ↗

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TCR selection and allelic exclusion in RAG transgenic mice that exhibit abnormal T cell localization in lymph nodes and lymphatics.Semantic proximity Read ↗

Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.Semantic proximity Read ↗

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V(D)J Recombination: Molecular Biology and RegulationSemantic proximity Read ↗

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