Article
Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.
Immunity - 1 May 1999
Gärtner F, Alt F W, Monroe R, Chu M, Sleckman B P, Davidson L, Swat W
Abstract excerpt
T cell receptor (TCR) beta chain allelic exclusion occurs at the thymocyte CD4- 8- (double-negative, or DN) to CD4+ 8+ (double-positive, or DP) transition, concurrently with differentiation and cellular expansion, and is imposed by a negative feedback loop in which a product of the first rearranged TCRbeta allele arrests further recombination in the TCRbeta locus. All of the major events associated with the...
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