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Article

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1 Aug 1993

Abstract excerpt

Peripheral T lymphocytes each express surface T cell receptor (TCR) alpha and beta chains of a single specificity. These are produced after random somatic rearrangements in TCR alpha and beta germline genes. Published model systems using mice expressing TCR alpha and/or beta chain transgenes have shown that allelic exclusion occurs conventionally for TCR-beta. TCR alpha chain expression, however, appears to be...

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PMID: 8393478
DOI: 10.1084/jem.178.2.615

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Source receipt: pubmed, retrieved 7 Sept 2026.

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