Article
The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2024
Culberson Erica J, Shields Kymberle C, Glynn Rebecca A, Allyn Brittney M, Hayer Katharina E, Bassing Craig H
Abstract excerpt
In jawed vertebrates, adaptive immunity depends on the process of V(D)J recombination creating vast numbers of T and B lymphocytes that each expresses unique Ag receptors of uniform specificity. The asynchronous initiation of V-to-(D)J rearrangement between alleles and the resulting protein from one allele signaling feedback inhibition of V recombination on the other allele ensures homogeneous receptor...
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