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Article

Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer.

Oncogene - 1 Oct 1991

Bennett W P, Hollstein M C, He A, Zhu S M, Resau J H, Trump B F, Metcalf R A, Welsh J A, Midgley C, Lane D P

Abstract excerpt

A strategy and methods for archival analysis of genetic and protein alterations in the p53 tumor-suppressor gene are presented. The tumor series includes 43 paraffin-embedded esophageal carcinomas from two high-incidence regions in the People's Republic of China. More than half contained elevated p53 protein levels which were detected by a high-titer polyclonal antiserum and a sensitive immunohistochemical...

Topics

Adenocarcinoma
Amino Acid Sequence
Carcinoma, Squamous Cell
China
Esophageal Neoplasms
Genes, p53
Humans
Molecular Sequence Data
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1923503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1923503-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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