Article
p53 mutations in esophageal tumors from a high incidence area of China in relation to patient diet and smoking history.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 1997
Bennett W P, von Brevern M C, Zhu S M, Bartsch H, Muehlbauer K R, Hollstein M C
Abstract excerpt
Esophageal tumors from 29 patients residing in Guangzhou, China were examined for mutations in exons 5-8 of the p53 tumor suppressor gene and for p53 protein accumulation in tumor cell nuclei. Anamnestic data for each patient, which included information on family history of cancer, tobacco smokin...
Topics
- Adenocarcinoma
- Adult
- Aged
- Carcinoma, Squamous Cell
- China
- DNA Mutational Analysis
- Diet
- Esophageal Neoplasms
- Exons
- Female
- Genes, p53