Article
Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia.
Annals of surgery - 1 Feb 2000
Ireland A P, Shibata D K, Chandrasoma P, Lord R V, Peters J H, DeMeester T R
Abstract excerpt
OBJECTIVE: To compare the frequency and spectrum of p53 gene mutations in adenocarcinomas of the esophagus and cardia and to compare clinical and pathologic features in patients with p53 mutant and nonmutant cancers. SUMMARY BACKGROUND DATA: The p53 gene is commonly mutated in human cancers, and a p53 mutation is reported to be present in more than 50% of esophageal adenocarcinomas. Although many studies have...
Topics
- Adenocarcinoma
- DNA, Neoplasm
- Esophageal Neoplasms
- Female
- Genes, p53
- Humans
- Male
- Middle Aged
- Mutation
- Polymorphism, Single-Stranded Conformational
- Stomach Neoplasms