Article
p53 protein expression does not correlate with EBV status in childhood B non-Hodgkin lymphomas.
Pediatric blood & cancer - 1 Aug 2004
Klumb C E, Hassan R, Zalcberg I R, Resende L M M, Carriço M K, Maia R C
Abstract excerpt
BACKGROUND: The p53 tumor suppressor gene is affected in a wide range of human cancers, including hematological malignancies. This gene encodes a nuclear phosphoprotein p53, which plays a key role in cell cycle arrest, induction of apoptosis, and DNA repair. Mutations of the p53 gene often lead to the accumulation of the mutated protein in the nucleus of neoplastic cells. However, p53 protein expression is...
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