Article
Cytoplasmic localization of wild-type p53 in glioblastomas correlates with expression of vimentin and glial fibrillary acidic protein.
Neuro-oncology - 1 Jul 2002
Sembritzki Olivier, Hagel Christian, Lamszus Katrin, Deppert Wolfgang, Bohn Wolfgang
Abstract excerpt
Cytoplasmic accumulation of wild-type p53 in tumor cells indicates that the tumor suppressor is inactive with regard to growth suppressive functions. Whether this occurs randomly during tumor development or characterizes a certain tumor cell subset is not known. Here we assayed primary glioblastomas for expression and subcellular localization of p53 and determined a correlation with expression of intermediate...
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