Article
Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1998
Isaacs J S, Hardman R, Carman T A, Barrett J C, Weissman B E
Abstract excerpt
Neuroblastoma (NB) cells in vitro are capable of bidirectional transdifferentiation, resulting in two distinct, yet reversible, phenotypes of neuroblastic (N-type) and nonneuronal (S-type) Schwann-like cells. Our previous studies suggested that the wild-type p53 protein is subject to differential regulation in a subset of neuronal cell types. To further test this hypothesis, we compared p53 function in three...
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