Article
When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein.
Cancer letters - 18 Jul 2003
Goldschneider David, Blanc Etienne, Raguenez Gilda, Haddada Hedi, Bénard Jean, Douc-Rasy Sétha
Abstract excerpt
In human neuroblastoma (NB), wild type p53 protein does not elicit its archetypal human tumor suppressive activity so far described. To elucidate this alteration, substantial investigations using NB cell lines have underscored p53 protein nuclear localization defect and/or inappropriate conformat...
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