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Article

The p53 pathway and its inactivation in neuroblastoma.

Cancer letters - 18 Jul 2003

Tweddle Deborah A, Pearson Andrew D J, Haber Michelle, Norris Murray D, Xue Chengyuan, Flemming Claudia, Lunec John

Abstract excerpt

Early studies of p53 in neuroblastoma reported infrequent mutations in tumours and cell lines. Cytoplasmic sequestration was later proposed as an alternative mechanism of inactivation, but many studies have since reported an intact p53 pathway in neuroblastoma cell lines, as detected by nuclear p...

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 12880966
DOI: 10.1016/s0304-3835(03)00088-0

Genes

MDM2
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12880966-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The p53 pathway and its inactivation in neuroblastoma.PMID 12880966Read ↗

Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G 1 Checkpoint after DNA DamageSemantic proximity Read ↗

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Outcome of the p53-mediated DNA damage response in neuroblastoma is determined by morphological subtype and MYCN expression.Semantic proximity Read ↗

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p53 determines multidrug sensitivity of childhood neuroblastoma.Semantic proximity Read ↗

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Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptideSemantic proximity Read ↗

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p53 mutations and loss of p53 function confer multidrug resistance in neuroblastoma.Semantic proximity Read ↗

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