Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.

doi:10.3109/10428199809057539

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Article

Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.

Leukemia & lymphoma - 1 Jul 1998

Chapman C J, Wright D, Stevenson F K

Abstract excerpt

Analysis of usage of V(H) and V(L) genes, and the degree and pattern of somatic mutation, has been used to investigate the cell of origin and clonal history in cases of Burkitt's lymphoma (BL). Tumor cell lines and biopsy material from patients with endemic, sporadic and AIDS-associated BL have b...

Topics

Burkitt Lymphoma
DNA, Neoplasm
Genes, Immunoglobulin
Genetic Variation
Humans
Immunoglobulin Variable Region
Mutation

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