Article
Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.
Leukemia & lymphoma - 1 Jul 1998
Chapman C J, Wright D, Stevenson F K
Abstract excerpt
Analysis of usage of V(H) and V(L) genes, and the degree and pattern of somatic mutation, has been used to investigate the cell of origin and clonal history in cases of Burkitt's lymphoma (BL). Tumor cell lines and biopsy material from patients with endemic, sporadic and AIDS-associated BL have been compared. V(H) genes were most commonly derived from the V(H)3 (52%) and V(H)4 (39%) families. This shows a similar...
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