Article
Tracking of the V4-34 (VH4-21) gene in human tonsil reveals clonal isotype switch events and a highly variable degree of somatic hypermutation.
Clinical and experimental immunology - 1 Aug 1996
Chapman C J, Mockridge C I, Hamblin T J, Stevenson F K
Abstract excerpt
The V4-34 (VH4-21) gene has been found to encode certain IgM autoantibodies, and is mandatory for pathological IgM anti-erythrocyte antibodies of I/i specificity. The gene is also commonly used by normal IgM-positive B lymphocytes, but its involvement in B cells which have undergone class switchi...
Topics
- Amino Acid Sequence
- Autoantibodies
- Base Sequence
- Child
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Class Switching
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Male
- Molecular Sequence Data
- Mutation
- Palatine Tonsil