Article
Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity.
Blood - 15 Apr 1995
Chapman C J, Mockridge C I, Rowe M, Rickinson A B, Stevenson F K
Abstract excerpt
Tumor cell lines from six typical cases of endemic Epstein-Barr virus (EBV) genome-positive Burkitt's lymphoma (BL) have been investigated for usage and mutational pattern of Ig VH genes. The neoplastic cells all had a t(8;14) (q24;q32) translocation involving the c-myc protooncogene. The VH gene...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Burkitt Lymphoma
- DNA Mutational Analysis
- DNA, Neoplasm
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Sequence Alignment
- Sequence Homology
- Tumor Cells, Cultured