Article
Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60.
Molecular and cellular biology - 1 May 1995
Rassow J, Mohrs K, Koidl S, Barthelmess I B, Pfanner N, Tropschug M
Abstract excerpt
We studied the role of mitochondrial cyclophilin 20 (CyP20), a peptidyl-prolyl cis-trans isomerase, in preprotein translocation across the mitochondrial membranes and protein folding inside the organelle. The inhibitory drug cyclosporin A did not impair membrane translocation of preproteins, but...
Topics
- Amino Acid Isomerases
- Amino Acid Sequence
- Base Sequence
- Carrier Proteins
- Chaperonin 60
- Chaperonins
- DNA Primers
- DNA, Fungal
- Enzyme Precursors
- Genes, Fungal
- HSP70 Heat-Shock Proteins
- Mitochondria
- Models, Biological
- Molecular Sequence Data
- Mutation
- Neurospora crassa
- Peptidylprolyl Isomerase
- Protein Folding