Article
Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins.
Molecular and cellular biology - 1 Dec 1995
Laloraya S, Dekker P J, Voos W, Craig E A, Pfanner N
Abstract excerpt
Mitochondrial GrpE (Mge1p) is a mitochondrial cochaperone essential for viability of the yeast Saccharomyces cerevisiae. To study the role of Mge1p in the biogenesis of mitochondrial proteins, we isolated a conditional mutant allele of MGE1 which conferred a temperature-sensitive growth phenotype...
Topics
- Alleles
- Amino Acid Sequence
- Carrier Proteins
- Conserved Sequence
- Fungal Proteins
- Genotype
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Membrane Transport Proteins
- Mitochondria
- Mitochondrial Membrane Transport Proteins
- Molecular Chaperones
- Molecular Sequence Data
- Mutagenesis, Insertional