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Article

Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.

The Journal of biological chemistry - 19 Jun 2009

Anandatheerthavarada Hindupur K, Sepuri Naresh Babu V, Avadhani Narayan G

Abstract excerpt

Previously we showed that xenobiotic inducible cytochrome P450 (CYP) proteins are bimodally targeted to the endoplasmic reticulum and mitochondria. In this study, we investigated the mechanism of delivery of chimeric signal containing CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocases (TOMs). CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22 for...

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Identifiers

PMID: 19401463
DOI: 10.1074/jbc.M109.007492
PMCID: PMC2719370

Genes

CYP27A1
CYP2E1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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