Article
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.
The Journal of cell biology - 1 Oct 1993
Gambill B D, Voos W, Kang P J, Miao B, Langer T, Craig E A, Pfanner N
Abstract excerpt
The role of mitochondrial 70-kD heat shock protein (mt-hsp70) in protein translocation across both the outer and inner mitochondrial membranes was studied using two temperature-sensitive yeast mutants. The degree of polypeptide translocation into the matrix of mutant mitochondria was analyzed usi...
Topics
- Amino Acid Sequence
- Biological Transport
- Cell Compartmentation
- Heat-Shock Proteins
- Mitochondria
- Molecular Sequence Data
- Mutation
- Neurospora crassa
- Protein Denaturation
- Protein Precursors
- Proton-Translocating ATPases
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae
- Sequence Analysis, DNA