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Article

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.

The Journal of cell biology - 1 Oct 1993

Gambill B D, Voos W, Kang P J, Miao B, Langer T, Craig E A, Pfanner N

Abstract excerpt

The role of mitochondrial 70-kD heat shock protein (mt-hsp70) in protein translocation across both the outer and inner mitochondrial membranes was studied using two temperature-sensitive yeast mutants. The degree of polypeptide translocation into the matrix of mutant mitochondria was analyzed using a matrix-targeted preprotein that was cleaved twice by the processing peptidase. A short amino-terminal segment of...

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Identifiers

PMID: 8408191
DOI: 10.1083/jcb.123.1.109
PMCID: PMC2119813

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A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.PMID 8408191Read ↗

The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.Semantic proximity Read ↗

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.Semantic proximity Read ↗

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.Semantic proximity Read ↗

Protein unfolding by the mitochondrial membrane potential.Semantic proximity Read ↗

Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.Semantic proximity Read ↗

Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins.Semantic proximity Read ↗

Mitochondrial Hsp70/MIM44 complex facilitates protein import.Semantic proximity Read ↗

Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane.Semantic proximity Read ↗

The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation.Semantic proximity Read ↗

The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.Semantic proximity Read ↗

Functional coupling of presequence processing and degradation in human mitochondria.Semantic proximity Read ↗

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.Semantic proximity Read ↗

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