Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.

doi:10.1038/348137a0

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Article

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.

Nature - 8 Nov 1990

Kang P J, Ostermann J, Shilling J, Neupert W, Craig E A, Pfanner N

Abstract excerpt

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in t...

Topics

Biological Transport
Cell Compartmentation
Cloning, Molecular
DNA Mutational Analysis
Fungal Proteins
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Mitochondria
Mutation
Protein Conformation
Protein Precursors
Protein Processing, Post-Translational
Protozoan Proteins

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Open in PubMed

Identifiers

PMID: 2234077
DOI: 10.1038/348137a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2234077-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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