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Article

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.

Nature - 8 Nov 1990

Kang P J, Ostermann J, Shilling J, Neupert W, Craig E A, Pfanner N

Abstract excerpt

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.

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Source

Identifiers

PMID: 2234077
DOI: 10.1038/348137a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.PMID 2234077Read ↗

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.Semantic proximity Read ↗

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Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins.Semantic proximity Read ↗

Identification of in vivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10.Semantic proximity Read ↗

Hsp78, a Clp homologue within mitochondria, can substitute for chaperone functions of mt-hsp70.Semantic proximity Read ↗

Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria.Semantic proximity Read ↗

Potential roles for mitochondria-to-HSF1 signaling in health and diseaseSemantic proximity Read ↗

The disaggregation activity of the mitochondrial ClpB homolog Hsp78 maintains Hsp70 function during heat stress.Semantic proximity Read ↗

Role of the mitochondrial DnaJ homolog Mdj1p as a chaperone for mitochondrially synthesized and imported proteins.Semantic proximity Read ↗

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.Semantic proximity Read ↗

Protein unfolding by the mitochondrial membrane potential.Semantic proximity Read ↗

A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation.Semantic proximity Read ↗

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