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Article

Protein unfolding by the mitochondrial membrane potential.

Nature structural biology - 1 Apr 2002

Huang Shihai, Ratliff Kevin S, Matouschek Andreas

Abstract excerpt

Mitochondria can unfold importing precursor proteins by unraveling them from their N-termini. However, how this unraveling is induced is not known. Two candidates for the unfolding activity are the electrical potential across the inner mitochondrial membrane and mitochondrial Hsp70 in the matrix. Here, we propose that many precursors are unfolded by the electrical potential acting directly on positively charged...

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Source

Identifiers

PMID: 11887183
DOI: 10.1038/nsb772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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