Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells.

Archives of biochemistry and biophysics - 1 Jan 2009

Tazawa Hidejiro, Fujita Chisako, Machida Kiyotaka, Osada Hiroyuki, Ohta Yoshihiro

Abstract excerpt

The mitochondrial permeability transition (MPT) is involved in both Ca(2+) signaling and cell death. The present study aimed to clarify the involvement of cyclophilin D, a peptidyl prolyl cis-trans isomerase (PPIase), in MPT induction in intact cells. To achieve this, we used C6 cells overexpressing wild-type or PPIase-deficient cyclophilin D, and measured the inner mitochondrial membrane permeability to calcein,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cyclophilins
Share to Fluoresceins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Dyes

Share to Ionomycin

Share to Mitochondrial Membranes

Share to Peptidylprolyl Isomerase

Share to Permeability

Source

Identifiers

PMID: 18996353
DOI: 10.1016/j.abb.2008.10.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells.PMID 18996353Read ↗

Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.Semantic proximity Read ↗

Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death.Semantic proximity Read ↗

Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2.Semantic proximity Read ↗

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.Semantic proximity Read ↗

Redox characterization of human cyclophilin D: identification of a new mammalian mitochondrial redox sensor?Semantic proximity Read ↗

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore.Semantic proximity Read ↗

Anastrozole mediated modulation of mitochondrial activity by inhibition of mitochondrial permeability transition pore opening: An initial perspectiveSemantic proximity Read ↗

Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60.Semantic proximity Read ↗

Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury.Semantic proximity Read ↗

Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice.Semantic proximity Read ↗

Hypoxic preconditioning-induced mitochondrial protection is not disrupted in a cell model of mtDNA T8993G mutation-induced F1F0-ATP synthase defect: the role of mitochondrial permeability transition.Semantic proximity Read ↗

Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shiftSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.