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Article

Identification of in vivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10.

The EMBO journal - 15 Oct 1998

Dubaquié Y, Looser R, Fünfschilling U, Jenö P, Rospert S

Abstract excerpt

The mechanism of chaperonin-assisted protein folding has been mostly analyzed in vitro using non-homologous substrate proteins. In order to understand the relative importance of hsp60 and hsp10 in the living cell, homologous substrate proteins need to be identified and analyzed. We have devised a novel screen to test the folding of a large variety of homologous substrates in the mitochondrial matrix in the...

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Identifiers

PMID: 9774331
DOI: 10.1093/emboj/17.20.5868
PMCID: PMC1170914

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