Article
p53 mutations occur in clinical, but not latent, human prostate carcinoma.
Japanese journal of cancer research : Gann - 1 Jan 1995
Konishi N, Hiasa Y, Hayashi I, Matsuda H, Tsuzuki T, Ming T, Kitahori Y, Shiraishi T, Yatani R, Shimazaki J
Abstract excerpt
To elucidate the role of the p53 tumor suppressor gene in prostate tumorigenesis, we probed for mutations in latent and clinical prostate cancers using single strand conformation polymorphism (SSCP) and restriction fragment length polymorphism (RFLP) analysis in combination with direct gene seque...
Topics
- Base Sequence
- DNA, Neoplasm
- Genes, p53
- Humans
- Immunohistochemistry
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational
- Prostatic Neoplasms
- Sequence Analysis, DNA