Article
p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network.
Journal of the National Cancer Institute - 1 Jan 1997
Gumerlock P H, Chi S G, Shi X B, Voeller H J, Jacobson J W, Gelmann E P, deVere White R W
Abstract excerpt
BACKGROUND: The reported frequency of mutation of the p53 tumor suppressor gene (also known as TP53) in human carcinomas of the prostate has varied widely, ranging from 3% to 42%. This variability may be a consequence of tumor heterogeneity and/or the use of different methods of analysis. Since p53 mutation has been associated with clinical outcome for a number of cancer types, determination of its true frequency...
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