Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutations in prostate cancer bone metastases suggest that selected p53 mutants in the primary site define foci with metastatic potential.

The Journal of urology - 1 Jan 1999

Navone N M, Labate M E, Troncoso P, Pisters L L, Conti C J, von Eschenbach A C, Logothetis C J

Abstract excerpt

PURPOSE: This study was undertaken to establish the pattern of specific p53 gene mutations in prostate cancer within primary tumors and distant metastases. MATERIALS AND METHODS: We performed polymerase chain reaction-single-strand conformation polymorphism and sequencing analyses of p53 exons 5-8 in DNA extracted from 22 formalin-fixed, paraffin-embedded tissues from 17 patients. Samples from three patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Immunohistochemistry

Share to Mutation

Share to Prostate Cancer Treatment and Research

Share to Prostatic Neoplasms

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 10037428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutations in prostate cancer bone metastases suggest that selected p53 mutants in the primary site define foci with metastatic potential.PMID 10037428Read ↗

Very frequent p53 mutations in metastatic prostate carcinoma and in matched primary tumors.Semantic proximity Read ↗

p53 gene alterations in human prostate carcinoma.Semantic proximity Read ↗

p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network.Semantic proximity Read ↗

Frequency and characterization of p53 mutations in clinically localized prostate cancer.Semantic proximity Read ↗

Frequency and characterization of p53 mutations in primary and metastatic human prostate cancer.Semantic proximity Read ↗

Alterations of the P53 gene are associated with the progression of a human prostate carcinoma.Semantic proximity Read ↗

p53 oncogene mutations in human prostate cancer specimens.Semantic proximity Read ↗

P53 tumour-suppressor gene mutations are mainly localised on exon 7 in human primary and metastatic prostate cancer.Semantic proximity Read ↗

Prediction of Metastatic Site Based On Somatic Gene Mutations in Primary Tumors in Prostate CancerSemantic proximity Read ↗

Bone metastasis in prostate cancer: Recurring mitochondrial DNA mutation reveals selective pressure exerted by the bone microenvironment.Semantic proximity Read ↗

p53 Immunostaining guided laser capture microdissection (p53-LCM) defines the presence of p53 gene mutations in focal regions of primary prostate cancer positive for p53 protein.Semantic proximity Read ↗

Tumor suppressor gene p53 mutations in human prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.