Article
p53 oncogene mutations in human prostate cancer specimens.
The Journal of urology - 1 Feb 1994
Voeller H J, Sugars L Y, Pretlow T, Gelmann E P
Abstract excerpt
Eighty-five prostate cancer specimens from prostate resections were analyzed for the presence of p53 gene mutations by immunohistochemical staining for P53 protein. DNA from thirty-four of these samples was also analyzed for mutations in exons 5-8 by single-strand chain polymorphism (SSCP) analys...
Topics
- Aged
- Aged, 80 and over
- Base Sequence
- DNA, Neoplasm
- DNA, Single-Stranded
- Genes, p53
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymorphism, Restriction Fragment Length
- Prostatic Neoplasms
- Proto-Oncogenes
- Tumor Suppressor Protein p53