Alterations of the P53 gene are associated with the progression of a human prostate carcinoma.

Abstract excerpt

P53 is a tumor suppressor gene that has been implicated in the molecular genetics of many human malignancies. Nucleotide alterations, most commonly single point mutations, have been shown not only to abrogate the p53 suppressor function but also to contribute to the transformed phenotype. We report the detection of a p53 gene mutation in clinical specimens of a patient with relapsing prostate adenocarcinoma 14...

Topics

• Adenocarcinoma
• Aged
• Base Sequence
• Chromosome Deletion
• DNA Mutational Analysis
• Genes, p53
• Humans
• Male
• Molecular Sequence Data
• Mutation
• Polymorphism, Restriction Fragment Length