Article
Abnormal p53 expression is rare in clinically localized human prostate cancer: comparison between immunohistochemical and molecular detection of p53 mutations.
The Prostate - 1 Jun 1997
Mottaz A E, Markwalder R, Fey M F, Klima I, Merz V W, Thalmann G N, Ball R K, Studer U E
Abstract excerpt
BACKGROUND: We assessed the frequency and molecular basis of p53 mutations in clinically localized prostatic adenocarcinoma. METHODS: Prostate specimens were examined from 100 patients with clinically localized prostatic adenocarcinoma and 13 patients with benign prostatic hyperplasia (BPH). Muta...
Topics
- Adenocarcinoma
- Adult
- Aged
- DNA
- Genes, p53
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prostatic Neoplasms
- Tumor Suppressor Protein p53