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Article

p53 gene alterations in human prostate carcinoma.

The Journal of urology - 1 Jul 1993

Effert P J, McCoy R H, Walther P J, Liu E T

Abstract excerpt

Alterations of the p53 gene are among the most frequent genetic lesions in a variety of human malignancies. Their role in prostate cancer is, however, unclear. We have analyzed 10 primary and two metastatic human prostate carcinomas as well as 3 prostate cancer cell lines for mutations of the p53-gene. Using single strand conformational polymorphism analysis (SSCP) and direct sequencing of the polymerase chain...

Topics

Brain Neoplasms
DNA, Neoplasm
Electrophoresis, Polyacrylamide Gel
Genes, p53
Humans
Lymphatic Metastasis
Male
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 8510267
DOI: 10.1016/s0022-5347(17)35458-7

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