Genotoxicity of agaritine in the lacI transgenic mouse mutation assay: evaluation of the health risk of mushroom consumption.

doi:10.1016/0278-6915(94)00142-b

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Article

Genotoxicity of agaritine in the lacI transgenic mouse mutation assay: evaluation of the health risk of mushroom consumption.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Apr 1995

Shephard S E, Gunz D, Schlatter C

Abstract excerpt

The mutagenic potency of the common mushroom Agaricus bisporus and crude agaritine extracted from mushrooms was determined in vivo using a new mutagenesis assay with lacI transgenic mice (Big Blue mice). Pairs of female lacI mice were fed one of three diets for 15 wk: (1) fresh mushrooms 3 days/wk followed by normal lab chow for 4 days/wk; (2) freeze-dried mushrooms mixed at 25% (w/w) into powdered chow; or (3) a...

Topics

Agaricus
Animals
Bacterial Proteins
DNA
DNA Damage
Escherichia coli Proteins
Female
Food Contamination
Food Handling
Gastric Mucosa
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney

Lac Repressors

Liver

Lung

Mice

Mice, Transgenic

Mushroom Poisoning

Source

Open in PubMed

Identifiers

PMID: 7737599
DOI: 10.1016/0278-6915(94)00142-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7737599-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genotoxicity of agaritine in the lacI transgenic mouse mutation assay: evaluation of the health risk of mushroom consumption.PMID 7737599Read ↗

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