Article
Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1999
de Boer J G, Mirsalis J C, Glickman B W
Abstract excerpt
We determined the spectrum of mutations in the lacI gene in the liver of Big Blue(R) transgenic mice after exposure to five daily doses of 2 mg/kg dimethylnitrosamine (DMN) at 3 and 6 weeks of age. This dose has been reported to increase the mutant frequency 9-fold when the animals are 3 weeks old. The lacI mutations recovered when treated at 3 weeks consist of mainly G:C --> A:T transitions, predominantly at...
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