Article
Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Carcinogenesis - 1 Apr 2008
Sandercock Linda E, Hahn Jennifer N, Li Li, Luchman H Artee, Giesbrecht Jennette L, Peterson Lisa A, Jirik Frank R
Abstract excerpt
It has been proposed that O(6)-methylguanine DNA methyltransferase (MGMT) gene silencing in premalignant lesions and cancers of the lung might result in the acquisition of a 'mutator' phenotype. Previously, however, we found that Mgmt(-/-) mouse DNA failed to show an increase in spontaneous mutations. We thus hypothesized that only during exposure to specific environmental carcinogens would the consequences of...
Topics
- Animals
- Carcinogens
- Crosses, Genetic
- DNA
- DNA Modification Methylases
- DNA Mutational Analysis
- DNA Repair Enzymes
- Female
- Genotype
- Male
- Mice