Article
Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice.
Mutation research - 10 Jul 1996
Suzuki T, Hayashi M, Ochiai M, Wakabayashi K, Ushijima T, Sugimura T, Nagao M, Sofuni T
Abstract excerpt
2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), which is a heterocyclic amine found in food and the potent mutagen in S. typhimurium TA98, was examined for its genotoxic potential using lacI transgenic mice (Big Blue, C57BL/6N lineage). Female mice, at 7 weeks of age, were given a diet contai...
Topics
- Animals
- Bone Marrow
- Colon
- Female
- Liver
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Micronucleus Tests
- Mutagens
- Mutation
- Quinolines
- Stomach