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Article

Exclusion of the Wilms tumour gene (WT1) promoter as a site of frequent mutation in Wilms tumour.

Oncogene - 20 Apr 1995

Grubb G R, Yun K, Reeve A E, Eccles M R

Abstract excerpt

WT1 is a tumour suppressor gene expressed in a specific temporal and spatial pattern in the developing kidney. Up to 15% of Wilms tumours have point mutations in the WT1 gene coding sequence. We have now investigated whether mutations in the WT1 promoter could be associated with loss of control WT1 expression and subsequent Wilms tumour formation. Using single-strand conformational polymorphism (SSCP) analysis we...

Topics

Base Sequence
Genes, Wilms Tumor
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Promoter Regions, Genetic
Wilms Tumor

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Identifiers

PMID: 7731725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7731725-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Exclusion of the Wilms tumour gene (WT1) promoter as a site of frequent mutation in Wilms tumour.PMID 7731725Read ↗

Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.Semantic proximity Read ↗

Fine structure analysis of the WT1 gene in sporadic Wilms tumors.Semantic proximity Read ↗

Insertional inactivation of the WT1 gene in tumour cells from a patient with WAGR syndrome.Semantic proximity Read ↗

Low frequency of mutations in the WT1 coding region in Wilms' tumor.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

Identification of a new WT1 mutation in a sporadic Wilms' tumour.Semantic proximity Read ↗

Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.Semantic proximity Read ↗

Familial predisposition to Wilms tumor does not segregate with the WT1 gene.Semantic proximity Read ↗

The genomic organization and expression of the WT1 gene.Semantic proximity Read ↗

Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumor.Semantic proximity Read ↗

Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours.Semantic proximity Read ↗

The third zinc finger of the WT1 gene is mutated in Wilms' tumour but not in a broad range of other urogenital tumours.Semantic proximity Read ↗

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