Article
Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours.
Oncogene - 1 Apr 1992
Little M H, Dunn R, Byrne J A, Seawright A, Smith P J, Pritchard-Jones K, van Heyningen V, Hastie N D
Abstract excerpt
Observations of non-random maternal 11p allele loss in Wilms' tumour (WT) have implied the possible involvement of an imprinted 11p locus in WT aetiology. A proposed 11p13 Wilms' tumour gene, WT1, has recently been isolated and encodes a zinc finger DNA-binding protein, the 3' untranslated region of which contains a polymorphic dinucleotide repeat (CA repeat) motif. We have exploited this transcribed CA repeat to...
Topics
- Alleles
- Base Sequence
- Chromosomes, Human, Pair 11
- DNA-Binding Proteins
- Gene Expression
- Genes, Tumor Suppressor
- Humans
- Imprinting, Psychological
- Molecular Sequence Data
- Oligodeoxyribonucleotides