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Article

Identification of a new WT1 mutation in a sporadic Wilms' tumour.

Biochimica et biophysica acta - 14 Aug 1998

Santos A C, Boavida M G, Costa A, Osorio-Almeida L

Abstract excerpt

A new mutation in WT1 is described in a sporadic unilateral Wilms' tumour consisting of a 17 bp duplication in exon 7 generating a stop codon. The second allele is either partially deleted or presents the same alteration. LOH analysis at 11p15.5 and at the 16q13-16q24.3 regions indicated retention of heterozygosity in the tumour DNA for the markers analysed. The results are consistent with Knudson's hypothesis...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9685601
DOI: 10.1016/s0925-4439(98)00032-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Identification of a new WT1 mutation in a sporadic Wilms' tumour.PMID 9685601Read ↗

Genome-wide loss of heterozygosity analysis of WT1-wild-type and WT1-mutant Wilms tumors.Semantic proximity Read ↗

Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.Semantic proximity Read ↗

Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.Semantic proximity Read ↗

WT1, WTX and CTNNB1 mutation analysis in 43 patients with sporadic Wilms' tumor.Semantic proximity Read ↗

Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours.Semantic proximity Read ↗

Exclusion of the Wilms tumour gene (WT1) promoter as a site of frequent mutation in Wilms tumour.Semantic proximity Read ↗

The familial Wilms' tumour susceptibility gene, FWT1, may not be a tumour suppressor gene.Semantic proximity Read ↗

Confirmation of FWT1 as a Wilms' tumour susceptibility gene and phenotypic characteristics of Wilms' tumour attributable to FWT1.Semantic proximity Read ↗

Constitutional and somatic mutations in the WT1 gene in Wilms' tumor patients.Semantic proximity Read ↗

Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors.Semantic proximity Read ↗

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