Article
Insertional inactivation of the WT1 gene in tumour cells from a patient with WAGR syndrome.
Human genetics - 1 Aug 1993
Santos A, Osorio-Almeida L, Baird P N, Silva J M, Boavida M G, Cowell J
Abstract excerpt
The WT1 gene was analysed using DNA from a Wilms' tumour derived from a patient with the WAGR syndrome using single strand conformation polymorphism analysis and polymerase chain reaction sequencing. A 14-bp insertion was found in the intron part of the splice donor site of exon 7 and was a tande...
Topics
- Abnormalities, Multiple
- Alleles
- Base Sequence
- Child, Preschool
- Chromosomes, Human, Pair 11
- DNA
- Female
- Gene Deletion
- Genes, Wilms Tumor
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Syndrome
- Tumor Cells, Cultured
- Wilms Tumor