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Article

Insertional inactivation of the WT1 gene in tumour cells from a patient with WAGR syndrome.

Human genetics - 1 Aug 1993

Santos A, Osorio-Almeida L, Baird P N, Silva J M, Boavida M G, Cowell J

Abstract excerpt

The WT1 gene was analysed using DNA from a Wilms' tumour derived from a patient with the WAGR syndrome using single strand conformation polymorphism analysis and polymerase chain reaction sequencing. A 14-bp insertion was found in the intron part of the splice donor site of exon 7 and was a tandem duplication of an upstream exon sequence. This mutation would be expected to disrupt the correct processing of the...

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Identifiers

PMID: 8396067
DOI: 10.1007/BF00216151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insertional inactivation of the WT1 gene in tumour cells from a patient with WAGR syndrome.PMID 8396067Read ↗

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The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient.Semantic proximity Read ↗

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Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.Semantic proximity Read ↗

The genomic organization and expression of the WT1 gene.Semantic proximity Read ↗

<i>WTX</i> inactivation is a frequent, but late event in Wilms tumors without apparent clinical impactSemantic proximity Read ↗

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