Article
The third zinc finger of the WT1 gene is mutated in Wilms' tumour but not in a broad range of other urogenital tumours.
Anticancer research - 1 Jan 2000
Quek H H, Chow V T, Tock E P
Abstract excerpt
Aberrations in the WT1 tumour suppressor gene have been documented in a fraction of Wilms' tumours (WTs). Encoding a protein with four zinc fingers, the WT1 gene is expressed in the developing kidney, gonads, uterus, spleen, mesothelium and brain. Using polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis and direct DNA sequencing, we analysed 156 diverse tumours for...
Topics
- Base Sequence
- Genes, Wilms Tumor
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Urogenital Neoplasms
- Zinc Fingers