Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.

Article

Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.

Oncogene - 1 Nov 1992

Baird P N, Groves N, Haber D A, Housman D E, Cowell J K

Abstract excerpt

Individuals with constitutional, heterozygous deletions of chromosome region 11p13 are predisposed to the development of Wilms' tumour, indicating the site of the tumour predisposition gene. The WT1 gene is a candidate for this cancer predisposition gene. If this gene is truly involved in tumorig...

Topics

Base Sequence
Heterozygote
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation
Oncogenes
Polymerase Chain Reaction
Syndrome
Wilms Tumor

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