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Article

Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumor.

Journal of biochemistry - 1 Mar 2003

Satoh Yuji, Nakagawachi Tetsuji, Nakadate Hisaya, Kaneko Yasuhiko, Masaki Zenjiro, Mukai Tsunehiro, Soejima Hidenobu

Abstract excerpt

WT1 at 11p13 is a tumor suppressor gene, an aberration of which causes Wilms' tumor (WT). Since WT1 expression is reduced in a certain proportion of WTs and its mutation is found only in 10-20% of WTs, we examined WT1 gene silencing due to epigenetic alteration in a total of 22 WTs. WT1 expression was significantly reduced in half of WTs without any mutation in the WT1 gene itself, suggesting that the reduction...

Topics

Base Sequence
Epigenesis, Genetic
Fetus
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation
WT1 Proteins
Wilms Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12761165
DOI: 10.1093/jb/mvg041

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