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Article

Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumor.

Journal of biochemistry - 1 Mar 2003

Satoh Yuji, Nakagawachi Tetsuji, Nakadate Hisaya, Kaneko Yasuhiko, Masaki Zenjiro, Mukai Tsunehiro, Soejima Hidenobu

Abstract excerpt

WT1 at 11p13 is a tumor suppressor gene, an aberration of which causes Wilms' tumor (WT). Since WT1 expression is reduced in a certain proportion of WTs and its mutation is found only in 10-20% of WTs, we examined WT1 gene silencing due to epigenetic alteration in a total of 22 WTs. WT1 expression was significantly reduced in half of WTs without any mutation in the WT1 gene itself, suggesting that the reduction...

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PMID: 12761165
DOI: 10.1093/jb/mvg041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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