Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype.

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Article

Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype.

American journal of human genetics - 1 Apr 1996

Gudmundsson J, Johannesdottir G, Arason A, Bergthorsson J T, Ingvarsson S, Egilsson V, Barkardottir R B

Abstract excerpt

Cloning of a breast cancer-predisposing gene (BRCA2) on chromosome 13Q12-14 has been reported recently. We analyzed seven large Icelandic breast cancer families with markers from the BRCA2 region. Five families showed strong evidence of linkage. The maximum two-point LOD scores for the five BRCA2...

Topics

Aged
BRCA2 Protein
Breast Neoplasms
Chromosomes, Human, Pair 13
Female
Genetic Linkage
Genetic Markers
Haplotypes
Heterozygote
Humans
Iceland
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Neoplasm Proteins

Neoplasms

Ovarian Neoplasms

Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 8644738
PMCID: PMC1914693

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8644738-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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