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Article

Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer.

International journal of cancer - 10 May 2002

Osorio Ana, de la Hoya Miguel, Rodríguez-López Raquel, Martínez-Ramírez Angel, Cazorla Alicia, Granizo Juan José, Esteller Manel, Rivas Carmen, Caldés Trinidad, Benítez Javier

Abstract excerpt

The BRCA1 and BRCA2 genes are responsible for a high proportion of familial breast cancer; germline mutations in these genes confer a lifetime risk of about 70% for developing breast cancer. Most of the described deleterious mutations are small deletions or insertions that originate a truncated protein; however, in many cases, they are amino acid changes whose significance is unknown. In these cases, there are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11979449
DOI: 10.1002/ijc.10337

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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