Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions.

Abstract excerpt

Somatic loss of heterozygosity (LOH) has been widely reported in breast cancer as a means of identifying putative tumor-suppressor genes. However, individual studies have rarely spanned more than a single chromosome, and the varying criteria used to declare LOH complicate efforts to formally differentiate regions of consistent versus sporadic (random) loss. We report here the compilation of an extensive database...

Topics

• Alleles
• Breast Neoplasms
• Chromosome Mapping
• Chromosomes, Human, Pair 17
• Female
• Genes, Tumor Suppressor
• Genetic Markers
• Genome, Human
• Humans
• Loss of Heterozygosity